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"A mouth rinse used to identify oral microbiome composition could serve as an early-detection tool for gastric cancer, new evidence suggests. Researchers found distinct bacterial composition differences in patient samples that point to the potential for oral microbial signatures to be used as biomarkers for assessing gastric cancer risk."
"The researchers analyzed the samples for alpha and beta diversity and conducted differential analysis using the framework called analysis of compositions of microbiomes.
They found distinct differences between the oral microbiomes of the healthy group and those of the groups with gastric cancer and pre–gastric cancer. In addition, the microbiomes of participants with cancer and of those with precancerous conditions were similar.
The oral microbiome may serve as a window into the composition of the stomach environment, Perati (researcher) said
The microbiome can vary between people and within the same individual over time. Probiotics, antibiotics, and diet can lead to changes in the microbiome. When asked how these changes could affect the accuracy of an oral rinse test, Perati said
"it's known that, in general, dietary modifications can have an impact on the diversity and the prevalence of certain bacteria throughout the GI tract."
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