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""There's not a lot of evidence that sweeteners like sucralose provide significant benefits, especially over the long term," Susan Swithers, PhD, professor, Department of Psychological Sciences and associate dean for Faculty Affairs at Purdue University"
"Swithers authored an article several years ago cautioning that consuming non-nutritive sweeteners in beverages not only fails to prevent disease but also is associated with an increase in risks for the same health outcomes associated with sugar-sweetened beverages, including T2D, cardiovascular disease, hypertension, and stroke.
At this point, we have pretty good evidence that these chemicals that were once touted as being completely inert are, in fact, not inert," she said. "We know that they're unlikely to be toxic in the short term, but they are not benign, and they have consequences.
In 2023, the World Health Organization (WHO) released a guideline on NSS that recommended against their use for weight control or to reduce the risk for noncommunicable diseases. The systematic review and meta-analysis upon which the guideline is based found that high intakes of NSS were associated with increases in body mass index and, as Swithers found, risks of developing T2D, cardiovascular events, and any type of stroke, as well as hypertension, bladder cancer, and all-cause mortality."
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